The overall goal of our research is to develop innovative methodologies in organic and bioorganic chemistry to address problems in biology.  We are particularly interested in the use of small molecules to probe dynamic processes in biological systems.  In this respect, we are developing microarray-based tools to measure enzymatic activity on a proteomic scale using small molecules designed to query the activity individual enzymes.  We are also synthesising libraries of inhibitors designed based on the mechanism of specific enzyme classes or based on natural products which have been selected by evolution for specific function.  We are also interested in imaging technologies to visualize biological events such as gene expression in vivo.

      Our laboratories are located in the Institut de Science et d'Ingénierie Supramoléculaires (ISIS) on the central campus of university Louis Pasteur in the heart of Strasbourg.  The institute, founded by Jean-Marie Lehn, was inaugurated in 2003 and includes research groups spanning the fields of biophysics, nanotechnology, molecular biology, chemical biology and supramolecular sciences.