Laboratoire de Chimie et reconnaissance de Biomolécules : Publications

V.A. Soldatenkov, A.A. Vetcher, T. Duka, S. Ladame, ACS Chem. Biol., 2008, 3, 214-219. First evidence of a functional interaction between DNA quadruplexes and poly(ADP-ribose) polymerase-1.

S. Ladame, Org. Biomol. Chem., 2008, 6, 219-226. Dynamic Combinatorial Chemistry: on the road to fulfilling the promise.

P.S. Shirude, E.R. Gillies, S. Ladame, F. Godde, K. Shin-Ya, I. Huc, S. Balasubramanian, J. Am. Chem. Soc., 2007, 129, 11890-11891. Macrocyclic and Helical Oligoamides as a New Class of G-Quadruplex Ligands.

J. E. Redman, S. Ladame, A.P. Reszka, S. Neidle, S. Balasubramanian Org. Biomol. Chem., 2006, 4, 4364-4369. Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library.

K. Jantos, R. Rodriguez, S. Ladame, P. Shirude, S. Balasubramanian J. Am. Chem. Soc., 2006, 128, 13662-13663. Oxazole-based Peptide Macrocycles : A new Class Of G-Quadruplex Binding Ligands.

D.P.N. Gonçalves, S. Ladame, S. Balasubramanian, J.K.M. Sanders Org. Biomol. Chem., 2006, 4, 3337-3342. Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins.

J.J. Green, S. Ladame, L. Ying, D. Klenerman, S. Balasubramanian J. Am. Chem. Soc., 2006, 128, 9809-9812. Investigating a Quadruplex- Ligand Interaction by Unfolding Kinetics.

H. Fernando, A.P. Reszka, J. Huppert, S. Ladame, S. Rankin, A.R. Venkitaraman, S. Neidle, S. Balasubramanian Biochemistry, 2006, 45, 7854-7860. A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene.

S. Ladame, J.A. Schouten, J. Roldan, J.E. Redman, S. Neidle, S. Balasubramanian Biochemistry, 2006, 45, 1393-1399. Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein.

L. Azéma, R. Baron, S. Ladame Current Enzyme Inhibition (review), 2006, 2, 61-72. Targeting enzymes with phosphonate-based inhibitors : mimics of tetrahedral transition states and stable isosteric analogues of phosphates.

S. Ladame, A.M. Whitney, S. Balasubramanian Angew. Chem. Int. Ed., 2005, 44, 5736-5739. Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach. Highlighted in Nature Chem. Biol., 2005, 1(5), 251.

L. Azéma, S. Ladame, C. Lapeyre, A. Zwick, F. Lakhdar-Ghazal Spectrochim. Acta A, 2005, 62, 287-292. Does phosphoryl protonation occurs in aqueous phosphoesters solutions ?

S. Rankin, A.P. Reszka, J. Huppert, M. Zloh, G.N. Parkinson, A.K. Todd, S. Ladame, S. Balasubramanian, S. Neidle J. Am. Chem. Soc., 2005, 127 (30), 10584-10589. Putative DNA quadruplex formation within the human c-kit oncogene.

S. Ladame, R. Fauré, C. Denier, F. Lakhdar-Ghazal, M. Willson Org. Biomol. Chem., 2005, 3, 2070-2072. Selective inhibition of Trypanosoma cruzi GAPDH by “bi-substrate” analogues.

S. Ladame, J.A. Schouten, J. Stuart, J. Roldan, S. Neidle, S. Balasubramanian Org. Biomol. Chem., 2004, 2, 2925-2932. Tetrapeptides induce specific recognition for G-quadruplexes when conjugated to a DNA-binding platform.

S.D. Patel, M. Isalan, G. Gavory, S. Ladame, Y. Choo, S. Balasubramanian Biochemistry, 2004, 43, 13452-13458. Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes.

A.M. Whitney, S. Ladame, S. Balasubramanian Angew. Chem. Int. Ed., 2004, 43, 1143-1146. Templated Ligand Assembly by Using G-Quadruplex DNA and Dynamic Covalent Chemistry.

S. Ladame, M.S. Castilho, C.H.T.P. Silva, C. Denier, V. Hannaert, J. Périé, G. Oliva, M. Willson Eur. J. Biochem., 2003, 270, 4574-4586. Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid. Selective inhibition by structure-based design.

M. S. Castilho, F. Pavao, G. Oliva, S. Ladame, M. Willson, J. Périé Biochemistry, 2003, 42 (23), 7143-7151. Evidence for the Two Phosphate Binding Sites of an Analogue of the Thioacyl Intermediate for the Trypanozoma cruzi Glyceraldehyde-3-phosphate-Dehydrogenase Catalyzed- Reaction from its Crystal Structure.

J. A. Schouten, S. Ladame, S. J. Mason, M. A. Cooper, S. Balasubramanian J. Am. Chem. Soc., 2003, 125 (19), 5594-5595. Peptide-Hemicyanine based G- quadruplex ligands by partial combinatorial selection.

S. Ladame, R. J. Harrison, S. Neidle, S. Balasubramanian Org. Letters, 2002, 4 (15), 2509-2512. Solid-Phase Synthesis of Symmetrical 3,6-Bispeptide-Acridone Conjugates.

S. Ladame, M. Willson, J. Périé Eur. J. Org. chem., 2002, 15, 2640-2648. A Convenient Synthesis of Dibenzyl ?,?-Difluoromethyl-?-ketophosphonates.

S. Ladame, M. Bardet, J. Périé, M. Willson Bioorg. Med. Chem., 2001, 9, 773-783. Selective inhibition of Trypanosoma brucei GAPDH by 1,3-bisphospho-D-glyceric acid (1,3-diPG) analogues.

S. Ladame, S. Claustre, M. Willson Phosphorus, Sulfur, and Silicon, 2001, 174, 37-47. Selective phosphorylation on primary alcohols of unprotected polyols.

L. Nzita, S. Ladame, L. Gomez, S. Moreau Nucleosides & Nucleotides, 1997, 16, 1781-1784. Synthesis of a 2-hydroxy- oxolane derivative as a new potential crosslinking agent of DNA.