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Institut de Science et d'Ingénierie Supramoléculaires
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Différences
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| ~~NOTRANS~~ | ~~NOTRANS~~ | ||
| ====== Événements et actualité ====== | ====== Événements et actualité ====== | ||
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| ===== Prochains Événements ===== | ===== Prochains Événements ===== | ||
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| /* {{image_conf.png?750}} */ | /* {{image_conf.png?750}} */ | ||
| /* **Abstract**: bla bla bla */ | /* **Abstract**: bla bla bla */ | ||
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| + | __June 12, 2013:__ **Conference ISIS**, Prof. **Don HILVERT**, //"Evolution and application of protein capsids"//, ETH Zurich (Switzerland)*/ | ||
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| + | /* __May 17, 2013:__ **ISIS Inaugural Lecture**: **Guido PUPILLO** //"Keeping it cool: atoms and molecules below 1μK"// and **Thomas HERMANS** //"Self-assembly in and out of thermodynamic equilibrium"// */ | ||
| /* __May 2 2011:__ **International Year of Chemistry** 17h00, Prof. **Piero BAGLIONI**, //"Chemistry for the Conservation of Cultural Heritage: Preserving our past for a better future"//, University of Florence, Florence, (Italy) | /* __May 2 2011:__ **International Year of Chemistry** 17h00, Prof. **Piero BAGLIONI**, //"Chemistry for the Conservation of Cultural Heritage: Preserving our past for a better future"//, University of Florence, Florence, (Italy) | ||
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| The crystal structure of the yeast 80S ribosome reveals the higher complexity of eukaryotic ribosomes, which are 40% larger than their bacterial counterparts. The eukaryotic 80S and bacterial 70S ribosome shares 34 common proteins and eukaryotic ribosome has additional 45 unique proteins and bacterial ribosome has 22 additional unique proteins. The majority of eukaryotic specific elements of ribosomal RNA and proteins are located on the periphery of the conserved core. Our crystals capture the ribosome in two different conformations which are believed to reflect intermediate states in course of mRNA and tRNA translocation. | The crystal structure of the yeast 80S ribosome reveals the higher complexity of eukaryotic ribosomes, which are 40% larger than their bacterial counterparts. The eukaryotic 80S and bacterial 70S ribosome shares 34 common proteins and eukaryotic ribosome has additional 45 unique proteins and bacterial ribosome has 22 additional unique proteins. The majority of eukaryotic specific elements of ribosomal RNA and proteins are located on the periphery of the conserved core. Our crystals capture the ribosome in two different conformations which are believed to reflect intermediate states in course of mRNA and tRNA translocation. | ||
| Structural rearrangements of the ribosome in the tRNA binding step have been studied on bacterial ribosome model. Discrimination of tRNA on the ribosome occurs in two consecutive steps: initial selection and proofreading. We propose a proofreading mechanism based on comparison of crystal structures of the 70S ribosome with cognate or near-cognate tRNA. We have shown involvement of tales of ribosomal proteins in stabilization of correct tRNA on the ribosome. We suggest that proofreading begins with stabilization of tRNA anticodon loop with involvement of magnesium ions, following by stabilization of elbow region and accommodation of the acceptor end in the peptidyl transferase center. | Structural rearrangements of the ribosome in the tRNA binding step have been studied on bacterial ribosome model. Discrimination of tRNA on the ribosome occurs in two consecutive steps: initial selection and proofreading. We propose a proofreading mechanism based on comparison of crystal structures of the 70S ribosome with cognate or near-cognate tRNA. We have shown involvement of tales of ribosomal proteins in stabilization of correct tRNA on the ribosome. We suggest that proofreading begins with stabilization of tRNA anticodon loop with involvement of magnesium ions, following by stabilization of elbow region and accommodation of the acceptor end in the peptidyl transferase center. | ||
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| __March 26 2012:__ **Conference ISIS** 16h30, Prof. **Lyndon EMSLEY**, //"Surface Enhanced NMR Spectrosopy"//, ENS-Lyon (France) | __March 26 2012:__ **Conference ISIS** 16h30, Prof. **Lyndon EMSLEY**, //"Surface Enhanced NMR Spectrosopy"//, ENS-Lyon (France) | ||
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| In particular, sensitivity is a key problem in NMR, and we will demonstrate different approaches to increasing sensitivity. For example, we will show how surface NMR spectra can be greatly enhanced using DNP. Polarization is transferred from the protons of the solvent to the rare nuclei (at natural isotopic abundance) at the surface, yielding at up to a hundred-fold signal enhancement for surface species in silica frameworks. | In particular, sensitivity is a key problem in NMR, and we will demonstrate different approaches to increasing sensitivity. For example, we will show how surface NMR spectra can be greatly enhanced using DNP. Polarization is transferred from the protons of the solvent to the rare nuclei (at natural isotopic abundance) at the surface, yielding at up to a hundred-fold signal enhancement for surface species in silica frameworks. | ||
| As examples of this approach, we demonstrate the fast characterization of the distribution of surface bonding modes and interactions in a series of functionalized materials using this technique. Surface enhanced carbon-13, silicon-29, nitrogen-15 and aluminum-27 DNP NMR spectra were obtained by using incipient wetness impregnation of samples with a solution containing a polarizing radical. Furthermore, the remarkable gain in time provided by surface enhanced DNP NMR spectroscopy (up to a factor 10 000) allows the facile acquisition of two-dimensional correlation spectra, allowing access to conformational features of the surface groups | As examples of this approach, we demonstrate the fast characterization of the distribution of surface bonding modes and interactions in a series of functionalized materials using this technique. Surface enhanced carbon-13, silicon-29, nitrogen-15 and aluminum-27 DNP NMR spectra were obtained by using incipient wetness impregnation of samples with a solution containing a polarizing radical. Furthermore, the remarkable gain in time provided by surface enhanced DNP NMR spectroscopy (up to a factor 10 000) allows the facile acquisition of two-dimensional correlation spectra, allowing access to conformational features of the surface groups | ||
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| __April 2 2012:__ **Conference ISIS** 16h30, Prof. **Sylviane MULLER**, //"A single synthetic peptide for immunomodulating lupus, a chronic disabling autoimmune disease"//, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg (France) | __April 2 2012:__ **Conference ISIS** 16h30, Prof. **Sylviane MULLER**, //"A single synthetic peptide for immunomodulating lupus, a chronic disabling autoimmune disease"//, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg (France) | ||
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| **Abstract**: Autoimmune diseases are the consequence of immunity directed against the organism itself. The immune system abnormally recognizes self-components as foreign and produces antibodies, which are directed against normal cells and tissues. In systemic lupus erythematosus (SLE), which is characterized by inflammation and damage of various tissues (joints, skin, kidneys, heart, lungs, blood vessels, brain) at least 60 different antigens targeted by specific antibodies have been characterized. Current treatments of this multifactorial disease that can be fatal are mainly based on immunosuppressive drugs, which can lead to important side effects. The test of a series of overlapping peptides covering the U1-70K spliceosomal protein led us to identify a 21-mer phosphopeptide, called P140, able to significantly ameliorate the clinical and biological manifestations and prolong survival of treated lupus-prone mice. In a double-blind, placebo-controlled dose-ranging phase IIb clinical trials, P140 peptide was found to be safe and well tolerated by lupus patients, and significantly improved their clinical and biological status. The P140 underlying mechanism of action remains incompletely understood and structure-function studies are currently underway. P140 peptide influences the stability of class II MHC molecules and B lymphocyte antigen-processing cell functions, leading to a defect of autoreactive T cell stimulation. It also behaves as a so called “altered peptide ligand” of the T cell receptor that reorients the behaviour of autoreactive T cells. This multiplicity of targets might explain its initially unanticipated very potent efficacy to immunomodulate SLE, a highly complex autoimmune syndrome. | **Abstract**: Autoimmune diseases are the consequence of immunity directed against the organism itself. The immune system abnormally recognizes self-components as foreign and produces antibodies, which are directed against normal cells and tissues. In systemic lupus erythematosus (SLE), which is characterized by inflammation and damage of various tissues (joints, skin, kidneys, heart, lungs, blood vessels, brain) at least 60 different antigens targeted by specific antibodies have been characterized. Current treatments of this multifactorial disease that can be fatal are mainly based on immunosuppressive drugs, which can lead to important side effects. The test of a series of overlapping peptides covering the U1-70K spliceosomal protein led us to identify a 21-mer phosphopeptide, called P140, able to significantly ameliorate the clinical and biological manifestations and prolong survival of treated lupus-prone mice. In a double-blind, placebo-controlled dose-ranging phase IIb clinical trials, P140 peptide was found to be safe and well tolerated by lupus patients, and significantly improved their clinical and biological status. The P140 underlying mechanism of action remains incompletely understood and structure-function studies are currently underway. P140 peptide influences the stability of class II MHC molecules and B lymphocyte antigen-processing cell functions, leading to a defect of autoreactive T cell stimulation. It also behaves as a so called “altered peptide ligand” of the T cell receptor that reorients the behaviour of autoreactive T cells. This multiplicity of targets might explain its initially unanticipated very potent efficacy to immunomodulate SLE, a highly complex autoimmune syndrome. | ||
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| + | __May 21 2012:__ **Conference ISIS** 16h30, Prof. **Dieter SCHLÜTER**, //"Accessing covalent molecular objects and covalent monomolecular sheets"//, Department of Materials - ETH Zurich (Switzerland) | ||
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| + | **Abstract**: The presentation will cover two aspects of polymer chemistry. One is devoted to pushing synthesis to the level that covalent, shape-persistent objects are formed whose sizes reach biologically relevant dimensions and whose shape turns independent of environment. These objects are being made by sequential increase of cross-section thickness of conventional polymer chains using Merrifield-type chemistry (Figure 1 left). It will be shown how the largest ever structure-controlled molecule could be obtained this way and where the adventure presently stands. The other aspect deals with the generation of 2D polymers, that is monomolecular polymers with planar and laterally connecting repeat units (Figure 1 right). After a brief overview of “organic” and “polymer” approaches performed so far, the concepts will be presented which are presently being pursued in the author’s laboratory. They rest upon carefully designed monomers, interfacial as well as single crystalline ordering, and both metal-complexation and light-induced topochemical polymerizations. The lecture will provide a state-of-the-art picture including the first solution to the problem, which we consider an expansion of Staudinger’s polymerization concept. | ||
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| + | /* __June 25 2012:__ **Conference ISIS** 16h30, Prof. **Albert GOLDBETER**, //"Oscillatory Life: The Chemical Bases of Biological Rhythms"//, Faculté des Sciences, | ||
| + | Université Libre de Bruxelles (Belgium) | ||
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| + | **Abstract**: Rhythmic phenomena occur at all levels of biological organization, with periods ranging from milliseconds to years. Cellular rhythms originate from the regulatory feedback loops that control the dynamics of biochemical processes and represent a phenomenon of temporal self-organization. They illustrate how an emergent property, autonomous oscillatory behavior, arises from molecular interactions in regulatory networks. This explains why oscillatory phenomena abound at the cellular level. Biochemical oscillations and cellular rhythms can best be addressed by combining an experimental with a modeling approach. After providing an overview of biological rhythms and of their underlying mechanisms, I will focus on two major examples of rhythmic behavior at the cellular level: circadian clocks and the cell cycle. Computational models of increasing complexity allow us to address the molecular mechanism of circadian rhythms, as well as the dynamical bases of circadian clock-related physiological disorders. The mammalian cell cycle, driven by an enzymatic network of cyclin-dependent kinases, can also behave as a self-sustained oscillator. A model shows that the regulatory structure of this network results in its temporal self-organization in the form of sustained oscillations that bring about the orderly progression along cell cycle phases. The coupling of the cell cycle to the circadian clock results in the synchronization of these two major cellular rhythms. Rhythmic behavior is closely associated with cellular regulatory processes and therefore represents a dynamical property inherent to life. | ||
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| + | /* __October 1 2012:__ **Conference** 16h30, Prof. **Bartosz Andrej GRZYBOWSKI**, //"The micromechanics and physics of cancerous cells: What are the physical hallmarks of cancer metastasis?"//, Northwestern University & Non-equilibrium Energy Research Center (USA) | ||
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| + | **Abstract**: The mainstream research in cancer biology focuses on the genetic and molecular signatures underlying the disease. An alternative and perhaps more physics-oriented approach is to study cancer from a perspective of an entire cell treated as a complex system characterized by a set of micromechanical properties and cell-motility characteristics. In my lecture, I will talk about both of these aspects. In the context of micromechanics, I will first describe a new cell-tomography technique which allows for the reconstruction of 3D shapes of cells subject to well-defined, geometrically regular microconfinements. The reconstructed shapes allow for the derivation of an analytical micromechanics model that applies to various cell types. Somewhat unfortunately, analysis of cancerous vs. non-cancerous cells indicates little – if any – differences in their micromechanical properties. Thus, in search for the features distinguishing malignant from non-malignant cells the second part of the talk will focus on the ways in which cells move – again, over well defined microenvironments allowing for quantitative analyses. As I will show, non-cancerous and non-metastatic cells migrate in ways fundamentally different from metastatic cells. While non-metastatic cells are simple, diffusive random walkers, their non-metastatic variants employ space-searching strategies used by animal predators. In this spirit, metastatic “cellular predators” can be viewed as navigating optimally through human body in search for suitable conditions to thrive (as in the “seed and soil” theory). The lecture will close with examples of how the proteomic network controlling cell motility can be reprogrammed to revert the predatory walks of invasive cells into the benign, diffusive phenotype. | ||
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| + | /*__October 19 2012:__ **Conference** 14h00, Dr. **Sydney LEACH**, //"Origins of Life"//, Observatoire de Paris-Meudon (France) | ||
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| + | **Abstract**: In my presentation of ‘Origins of Life’ I plan to first bring up the problem of definitions of ‘origins’ and of ‘life’, then to discuss the operational definitions used by most scientists concerning the origins of life on Earth. These include the notions of metabolism, growth, replication and evolution. I will list the outstanding scientific problems in our attempts to understand these processes and their interrelations, including the origins of relevant prebiotic and biotic materials, The evidences from observations on extremophile life on Earth as well as our rapidly increasing knowledge of exoplanets lead to considering the possible existence of extraterrestrial life, which requires relevant criteria of proof. Mention will also be made of the problems of defining and identifying life based on biochemistries and energy sources different from those on Earth | ||
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| + | /*__October 22 2012:__ **Conference** 16h30, Prof. **Richard LAVERY**, //"Using molecular simulations to probe DNA recognition"//, Université de Lyon 1, IBCP (France) | ||
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| + | **Abstract**: DNA is an important target for both proteins and drugs. Proteins control all the processes linked to gene expression, DNA replication, DNA repair and DNA packaging within the cell. Many drugs also interact with DNA, or with protein-DNA complexes, to perturb, or block, these processes. It is consequently important to understand how these molecules locate their target sites within genomic DNA and, as a component of this process, how base sequence affects the structure and dynamics of DNA itself. I will present results from our ongoing projects in this area that notably exploit molecular dynamics simulations and free energy calculations to probe the details of the recognition process that are not easily accessible to experiment. | ||
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| + | /* *04/02/13 **Conference ISIS**, Prof. **Massimo OLIVUCCI**, //"From Computational Photobiology to the Design of Vibrationally Coherent Molecular Devices"//, Bowling Green State University (USA) & Università di Siena (Italy) | ||
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| + | **Abstract**: In the past multi-configurational quantum chemical computations have been employed to investigate spectroscopic, thermal and photochemical properties of visual pigments.1,2 Here we show how the same computational technology can nowadays be used to design, characterize and ultimately, prepare light-driven molecular switches which mimics the photophysics of the visual pigment bovine rhodopsin (Rh) 2,3. When embedded in the protein cavity the chromophore of Rh undergoes an ultrafast and coherent photoisomerization. In order to design a synthetic chromophore displaying similar properties in common solvents, we recently focused on indanylidene-pyrroline (NAIP) systems.3,4 We found that these systems display light-induced ground state coherent vibrational motion similar to the one detected in Rh. Semi-classical trajectories [top-right] provide a mechanistic description of the structural changes associated to the observed coherent motion [bottom-right] which is shown to be ultimately due to periodic changes in the π-conjugation. */ | ||
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| |[[http://www-isis.u-strasbg.fr/doc/Rencontre-10.03.08.pdf|{{http://www-isis.u-strasbg.fr/images/Rencontre-10.03.08.png?nolink}}]] |March 10th, 2008, Rencontre ISIS 17h15, Prof. **Michel Brunet** //"Origine des hominidés... Bilan et perspectives..."//, Collège de France, followed by a concert by Concert Trio "Trésors méconnus : Carl Reinecke et Alfred Uhl. | | |[[http://www-isis.u-strasbg.fr/doc/Rencontre-10.03.08.pdf|{{http://www-isis.u-strasbg.fr/images/Rencontre-10.03.08.png?nolink}}]] |March 10th, 2008, Rencontre ISIS 17h15, Prof. **Michel Brunet** //"Origine des hominidés... Bilan et perspectives..."//, Collège de France, followed by a concert by Concert Trio "Trésors méconnus : Carl Reinecke et Alfred Uhl. | | ||
| |[[http://www-isis.u-strasbg.fr/doc/Rencontres-ISIS-07.01.jpg|{{http://www-isis.u-strasbg.fr/images/Rencontres-ISIS-07.01.png?nolink}}]]|January 7th, 2008, Rencontre ISIS 17h15, **Pascal Dusapin** //"Les bords de la musique"// followed by a concert by Ensemble Accroche Note. | | |[[http://www-isis.u-strasbg.fr/doc/Rencontres-ISIS-07.01.jpg|{{http://www-isis.u-strasbg.fr/images/Rencontres-ISIS-07.01.png?nolink}}]]|January 7th, 2008, Rencontre ISIS 17h15, **Pascal Dusapin** //"Les bords de la musique"// followed by a concert by Ensemble Accroche Note. | | ||
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| + | ===== 2013 ===== | ||
| + | *08/04/2013 **Conference ISIS**, Prof.**David LEIGH**, //"Making the tiniest machines"//, University of Manchester (UK) | ||
| + | *18/03/13 **ISIS Mini-Symposium** //"Bridging Chemistry and Biology"//, **Bernd GIESE** (Switzerland) and **Katharina FROMM** (Switzerland) | ||
| + | *27/02/13 **Conference**, Prof. **Anne PETITJEAN**, //"Proton: a unique tool and trigger for supramolecular chemistry"//, Queen's University (Canada) | ||
| + | *04/02/13 **Conference ISIS**, Prof. **Massimo OLIVUCCI**, //"From Computational Photobiology to the Design of Vibrationally Coherent Molecular Devices"//, Bowling Green State University (USA) & Università di Siena (Italy) | ||
| + | *14/01/13 **Conference ISIS**, Prof. **Christoph GERBER**, //"AFM Technologie in Life science"//, University of Basel, Swiss Nanoscience Institut, NCCR (Switzerland) | ||
| ===== 2012 ===== | ===== 2012 ===== | ||
| + | *25/10/12 **ISIS Mini-Symposium //"From Nanochemistry to Functional Materials"//**, **Klaus MUELLEN** (Germany), **Clément SANCHEZ** (France) and **Roeland NOLTE** (the Netherlands)on the occasion of the presentation of the CNRS Silver Medal to Prof. Paolo Samorì | ||
| + | *22/10/12 **Conference ISIS**, Prof. **Richard LAVERY**, //"Using molecular simulations to probe DNA recognition"//, Université de Lyon 1, IBCP (France) | ||
| + | *19/10/12 **Conference**, Dr. **Sydney LEACH**, //"Origins of Life"//, Observatoire de Paris-Meudon (France) | ||
| + | *01/10/12 **Conference** Prof. **Bartosz GRZYBOWSKI**, //"The micromechanics and physics of cancerous cells: What are the physical hallmarks of cancer metastasis?"//, Northwestern University (USA) | ||
| + | *24/09/12 **ISIS Mini-Symposium "Complexity in Chemistry"**, **Michele PARRINELLO** (ETH, Switzerland), **Bartosz GRZYBOWSKI** (Northwestern University, USA) | ||
| + | *25/06/12 **Conference ISIS**, Prof. **Albert GOLDBETER**, //"Oscillatory Life: The Chemical Bases of Biological Rhythms"//, Faculté des Sciences, Université Libre de Bruxelles (Belgium) | ||
| + | *21/05/12 **Conference ISIS**, Prof. **Dieter SCHLÜTER**, //"Accessing covalent molecular objects and covalent monomolecular sheets"//, Department of Materials - ETH Zurich (Switzerland) | ||
| + | *02/04/12 **Conference ISIS**, Dr. **Sylviane MULLER**, //"A single synthetic peptide for immunomodulating lupus, a chronic disabling autoimmune disease"//, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg (France) | ||
| + | *26/03/12 **Conference ISIS**, Prof. **Lyndon EMSLEY**, //"Surface Enhanced NMR Spectrosopy"//, ENS-Lyon (France) | ||
| *31/01/12 **Conference ISIS**, Prof. **Antoine GEORGES**, //"Quantum Matter with Strong Correlations: from hot superconductors to cold atoms"//, Collège de France and Ecole Polytechnique (France) | *31/01/12 **Conference ISIS**, Prof. **Antoine GEORGES**, //"Quantum Matter with Strong Correlations: from hot superconductors to cold atoms"//, Collège de France and Ecole Polytechnique (France) | ||
| *16/01/12 **Conference ISIS**, Prof. **Marat YUSUPOV**, //"Crystal structures of bacterial and yeast ribosomes"//, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Université de Strasbourg (France) | *16/01/12 **Conference ISIS**, Prof. **Marat YUSUPOV**, //"Crystal structures of bacterial and yeast ribosomes"//, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Université de Strasbourg (France) | ||
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| *14/11/11: **International Year of Chemistry**, Prof. **Luisa DE COLA**, //"The Chemistry of Chocolate"//, Physikalisches Institut, Westfalische Wilhelms Universitat Munster, (Germany) | *14/11/11: **International Year of Chemistry**, Prof. **Luisa DE COLA**, //"The Chemistry of Chocolate"//, Physikalisches Institut, Westfalische Wilhelms Universitat Munster, (Germany) | ||
| *05/09/2011 **Conference ISIS**, Prof. **Jurgen RABE**, //"Graphenes, Nanographenes and Macromolecules - Hybrids for Optics, Electronics and Analytics"//, Humboldt University Berlin (Germany) | *05/09/2011 **Conference ISIS**, Prof. **Jurgen RABE**, //"Graphenes, Nanographenes and Macromolecules - Hybrids for Optics, Electronics and Analytics"//, Humboldt University Berlin (Germany) | ||
| - | *09/05/2011, 15h00, **ISIS Minisymposium "Chemical stability of the Genome"**, **Sidney HECHT** (Arizona State University, USA) and **Thomas CARELL** (Ludwig Maximilians Universität, Germany) {{:symp_may.pdf}} | + | *09/05/2011 **ISIS Minisymposium "Chemical stability of the Genome"**, **Sidney HECHT** (Arizona State University, USA) and **Thomas CARELL** (Ludwig Maximilians Universität, Germany) {{:symp_may.pdf}} |
| *02/05/2011, **International Year of Chemistry**, Prof. **Piero BAGLIONI**, //"Chemistry for the Conservation of Cultural Heritage: Preserving our past for a better future"//, University of Florence, Florence, (Italy) | *02/05/2011, **International Year of Chemistry**, Prof. **Piero BAGLIONI**, //"Chemistry for the Conservation of Cultural Heritage: Preserving our past for a better future"//, University of Florence, Florence, (Italy) | ||
| - | *01/04/2011, 14h00, **ISIS Minisymposium "Single-Molecule Biophysics"**, **Carlos BUSTAMANTE** (Berkeley, USA), **Michel ORRIT** (University of Leiden, the Netherlands) and **Attila SZABO** (National Institutes of Health, USA) {{:minisymp_avril2011.pdf|}} | + | *01/04/2011 **ISIS Minisymposium "Single-Molecule Biophysics"**, **Carlos BUSTAMANTE** (Berkeley, USA), **Michel ORRIT** (University of Leiden, the Netherlands) and **Attila SZABO** (National Institutes of Health, USA) {{:minisymp_avril2011.pdf|}} |
| - | *21/03/2011, 16h30, **Conference ISIS**, Prof. **Marie-France CARLIER**, //"Control of actin assembly in cell motility and morphogenesis: from molecules to reconstituted systems"//, LEBS Gif-sur-Yvette (France) | + | *21/03/2011 **Conference ISIS**, Prof. **Marie-France CARLIER**, //"Control of actin assembly in cell motility and morphogenesis: from molecules to reconstituted systems"//, LEBS Gif-sur-Yvette (France) |
| - | *15/03/2011, 14h30, **Minisymposium**, Jilin University (China) - ISIS UdS (France) | + | *15/03/2011 **Minisymposium**, Jilin University (China) - ISIS UdS (France) |
| - | *14/03/2011, 16h30, **Conference ISIS**, Prof. **George MALLIARAS**, //"Organic Electronics at the Interface with Biology"//, Ecole Nationale Supérieure des Mines de Saint Etienne (France) | + | *14/03/2011 **Conference ISIS**, Prof. **George MALLIARAS**, //"Organic Electronics at the Interface with Biology"//, Ecole Nationale Supérieure des Mines de Saint Etienne (France) |
| - | *06/03/2011, 17h00, **International Year of Chemistry 2011 - Inaugural Conference**, Prof. **Jean-Marie LEHN**, //"De la matière à la vie: chimie? chimie!"//, Université de Strasbourg (France) | + | *06/03/2011 **International Year of Chemistry 2011 - Inaugural Conference**, Prof. **Jean-Marie LEHN**, //"De la matière à la vie: chimie? chimie!"//, Université de Strasbourg (France) |
| - | *28/02/2011, 16h30, **Conference ISIS - Conference Le Bel**, Prof. **Sam STUPP**, //"Biological Signaling with Supramolecular Systems"//, Northwestern University, Illinois (USA) | + | *28/02/2011 **Conference ISIS - Conference Le Bel**, Prof. **Sam STUPP**, //"Biological Signaling with Supramolecular Systems"//, Northwestern University, Illinois (USA) |
| - | *21/02/2011, 16h30, **Conference ISIS**, Dr. **Bernd BRUCHMANN**, //"Dendridic Polymers - Academia meets Industry"//, BASF SE, Polymer Research, Ludwigshafen (Germany) | + | *21/02/2011 **Conference ISIS**, Dr. **Bernd BRUCHMANN**, //"Dendridic Polymers - Academia meets Industry"//, BASF SE, Polymer Research, Ludwigshafen (Germany) |
| - | *24/01/2011, 16h30, **Conference ISIS**, Prof. **Claudia VEIGEL**, //"Single Molecule Studies on Myosin Motors"//, Ludwig Maximilians Universität, München (Germany), http://www.cell.physiol.med.uni-muenchen.de/research_gr/veigel/index.html | + | *24/01/2011 **Conference ISIS**, Prof. **Claudia VEIGEL**, //"Single Molecule Studies on Myosin Motors"//, Ludwig Maximilians Universität, München (Germany), http://www.cell.physiol.med.uni-muenchen.de/research_gr/veigel/index.html |
| ===== 2010 ===== | ===== 2010 ===== | ||
| - | * 22/11/2010, 16h30, **Conference ISIS**, Prof. **Jean-Pierre SAUVAGE**, //"From Chemical Topology to Molecular Machines"//, Université de Strasbourg | + | * 22/11/2010 **Conference ISIS**, Prof. **Jean-Pierre SAUVAGE**, //"From Chemical Topology to Molecular Machines"//, Université de Strasbourg |
| - | * 19/11/2010, 9h00, **Conference ISIS**, Prof. **Paul CHAIKIN**, //"Self-Replication Without Life"//, New-York University | + | * 19/11/2010 **Conference ISIS**, Prof. **Paul CHAIKIN**, //"Self-Replication Without Life"//, New-York University |
| - | * 12/07/2010, 16h30, **Conference ISIS**, Prof. **Francesco STELLACCI**, //"Striped Nanoparticles: the tale of a novel Supramolecular Material"//, MIT & EPFL Lausanne | + | * 12/07/2010 **Conference ISIS**, Prof. **Francesco STELLACCI**, //"Striped Nanoparticles: the tale of a novel Supramolecular Material"//, MIT & EPFL Lausanne |
| - | * 31/05/2010, 17h15, **Conference ISIS - Conference Le Bel**, Prof. **Amir HOVEYDA**, //"Catalyst Development through Theory Solutions to Difficult Problems in Olefin Metathesis"//, Chemistry Department, Boston College, USA http://www2.bc.edu/~hoveyda/index.html | + | * 31/05/2010 **Conference ISIS - Conference Le Bel**, Prof. **Amir HOVEYDA**, //"Catalyst Development through Theory Solutions to Difficult Problems in Olefin Metathesis"//, Chemistry Department, Boston College, USA http://www2.bc.edu/~hoveyda/index.html |
| - | * 17/05/2010, **ISIS Minisymposium "Electron Transfer and Electronic transport"**{{:minisymposium_17.05.10_.pdf|}} | + | * 17/05/2010 **ISIS Minisymposium "Electron Transfer and Electronic transport"**{{:minisymposium_17.05.10_.pdf|}} |
| - | * 26/04/2010, 16h30, **Conference ISIS**, Dr. **Jean-François LUTZ**, //"Precision Macromolecular Chemistry: Controlling Macroscopic Properties via Advanced Polymer Design"//, Fraunhofer Institute for Applied Polymer Research, Potsdam, Germany, http://www.nano-lifescience.com/// | + | * 26/04/2010 **Conference ISIS**, Dr. **Jean-François LUTZ**, //"Precision Macromolecular Chemistry: Controlling Macroscopic Properties via Advanced Polymer Design"//, Fraunhofer Institute for Applied Polymer Research, Potsdam, Germany, http://www.nano-lifescience.com/// |
| - | * 18/01/2010, 17h00, **Conference ISIS**, Prof. **Helmuth MOHWALD**, //"Polymeric Capsules with Remote and Controlled Release for Bio-amd Materials science"//, Max-Planck-Institut für Kolloid - und Grenzflächenforschung – Potsdam (Allemagne), http://www.mpikg.mpg.de/index.html// | + | * 18/01/2010 **Conference ISIS**, Prof. **Helmuth MOHWALD**, //"Polymeric Capsules with Remote and Controlled Release for Bio-amd Materials science"//, Max-Planck-Institut für Kolloid - und Grenzflächenforschung – Potsdam (Allemagne), http://www.mpikg.mpg.de/index.html// |
| ===== 2009 ===== | ===== 2009 ===== | ||
| - | * 11/12/2009, 16h00, **Conference ISIS**, Prof. **Federico ROSEI**, //"Exploring Molecular Assembly At Surfaces"//, The NANO(meter)-FEMTO(second) LAB (NFL) , http://www.nanofemtolab.qc.ca// | + | * 11/12/2009 **Conference ISIS**, Prof. **Federico ROSEI**, //"Exploring Molecular Assembly At Surfaces"//, The NANO(meter)-FEMTO(second) LAB (NFL) , http://www.nanofemtolab.qc.ca// |
| - | * 24/11/2009, 11h00, **Conference**, Dr. **Marco CECCHINI**, //"Allosteric Communication in Myosin : from Small Conformational Changes to Large Directed Movements"//, Laboratoire de Chimie Biophysique - ISIS | + | * 24/11/2009 **Conference**, Dr. **Marco CECCHINI**, //"Allosteric Communication in Myosin : from Small Conformational Changes to Large Directed Movements"//, Laboratoire de Chimie Biophysique - ISIS |
| - | * 16/11/2009, 17h00, **Conference ISIS**, Prof. **Stefan HECHT**, //"Folding, Switching, and Stitching of Molecules"//, Department of Chemistry, Humboldt University Berlin, http://www.hechtlab.de/ | + | * 16/11/2009 **Conference ISIS**, Prof. **Stefan HECHT**, //"Folding, Switching, and Stitching of Molecules"//, Department of Chemistry, Humboldt University Berlin, http://www.hechtlab.de/ |
| - | * 09/11/2009, 16h00, **Conference ISIS**, Dr. **Olivier POURQUIE**, //"Segmentation, clocks and vertebrae"//, IGBMC - UMR 7104 - U.964 INSERM | + | * 09/11/2009 **Conference ISIS**, Dr. **Olivier POURQUIE**, //"Segmentation, clocks and vertebrae"//, IGBMC - UMR 7104 - U.964 INSERM |
| - | * 12/06/2009, 9h00-12h00, **Minisymposium** {{:aff_minisymposium_120609.pdf|programme}} | + | * 12/06/2009 **Minisymposium** {{:aff_minisymposium_120609.pdf|programme}} |
| - | * 08/06/2009, 17h00, Prof. **Hiroshi FUKUMURA**, //"Laser-induced phase separation dynamics of binary liquid systems and the application of dynamic solvents as reaction fields"//, Department of Chemistry, Tohuku University Japan | + | * 08/06/2009 **Conference** Prof. **Hiroshi FUKUMURA**, //"Laser-induced phase separation dynamics of binary liquid systems and the application of dynamic solvents as reaction fields"//, Department of Chemistry, Tohuku University Japan |
| - | * 05/05/2009, 17h00, **Conference ISIS**, Pr. **Luisa DE COLA**, //"Nanomaterials for imaging and therapy"//, Institut de Physique, Universite de Muenster, http://www.uni-muenster.de/Physik.PI/DeCola/ | + | * 05/05/2009 **Conference ISIS**, Pr. **Luisa DE COLA**, //"Nanomaterials for imaging and therapy"//, Institut de Physique, Universite de Muenster, http://www.uni-muenster.de/Physik.PI/DeCola/ |
| - | * February 27th, 2009, 14h30, Prof. **Audrey MOORES**, //"A coordination chemistry study of metal nanoparticles : how ligands affect the properties of nanoparticles."//, Department of Chemistry, McGill University, Montreal, Canada | + | * February 27th, 2009 Prof. **Audrey MOORES**, //"A coordination chemistry study of metal nanoparticles : how ligands affect the properties of nanoparticles."//, Department of Chemistry, McGill University, Montreal, Canada |
| - | * February 17th, 2009, 17h, Prof. **Maurizio PRATO**, //"Functionalization of Carbon Nanotubes for Materials and Biomedical Applications"//, Dipartimento di Scienze Farmaceutiche, University of Trieste, Italy | + | * February 17th, 2009 Prof. **Maurizio PRATO**, //"Functionalization of Carbon Nanotubes for Materials and Biomedical Applications"//, Dipartimento di Scienze Farmaceutiche, University of Trieste, Italy |
| - | * January 26th, 2009, Dr. **Daniel RIVELINE**, //"Auto-organisation aux échelles cellulaires et multicellulaires"//, Rockefeller University, Lab. of yeast genetics and cell biology (Nurse Lab.), New York | + | * January 26th, 2009 Dr. **Daniel RIVELINE**, //"Auto-organisation aux échelles cellulaires et multicellulaires"//, Rockefeller University, Lab. of yeast genetics and cell biology (Nurse Lab.), New York |
| - | * January 23rd, 2009, 10h30, Amphi 2, Institut Le Bel, Prof. **Ben FERINGA**, //"From Molecules to Molecular Systems, controlling movement at the nanoscale"//, [[http://feringa.fmns.rug.nl/|Groningen University]] | + | * January 23rd, 2009 Institut Le Bel, Prof. **Ben FERINGA**, //"From Molecules to Molecular Systems, controlling movement at the nanoscale"//, [[http://feringa.fmns.rug.nl/|Groningen University]] |
| ===== 2008 ===== | ===== 2008 ===== | ||
| - | * December 8th, 2008, 17h00, Prof. **Dino Moras**, //"Allosteric regulation of Nuclear Hormone Receptors activity"//, [[http://www.igbmc.fr/recherche/Dep_BSG/Eq_DMora/index.html|IGBMC]]. | + | * December 8th, 2008 Prof. **Dino Moras**, //"Allosteric regulation of Nuclear Hormone Receptors activity"//, [[http://www.igbmc.fr/recherche/Dep_BSG/Eq_DMora/index.html|IGBMC]]. |
| - | * November 17th, 2008, 17h00, Prof. **Rudi Glockshuber** //"Assembly of supramolecular structures: Insights from type 1 pili from uropathogenic Escherichia coli strains"//, [[http://www.mol.biol.ethz.ch/groups/glockshuber_group|link]] | + | * November 17th, 2008 Prof. **Rudi Glockshuber** //"Assembly of supramolecular structures: Insights from type 1 pili from uropathogenic Escherichia coli strains"//, [[http://www.mol.biol.ethz.ch/groups/glockshuber_group|link]] |
| - | * November 4th, 2008, 9h30, Prof. **Bernhard Breit** //"Supramolecular Concepts in Homogeneous Catalysis"//, Albert-Ludwigs Université de Fribourg-en-Brisgau, Allemagne | + | * November 4th, 2008 Prof. **Bernhard Breit** //"Supramolecular Concepts in Homogeneous Catalysis"//, Albert-Ludwigs Université de Fribourg-en-Brisgau, Allemagne |
| - | * October 3rd, 2008, 15h00, Prof. **Masahiro Irie** //"Photochromic Diarylethene Molecules and Crystals - Application to Molecular Machinery"//, Dpt of Chemistry, Rikkyo University, Tokyo (Japan). [[http://www-isis.u-strasbg.fr/doc/conf-IRIE.pdf|pdf]] | + | * October 3rd, 2008 Prof. **Masahiro Irie** //"Photochromic Diarylethene Molecules and Crystals - Application to Molecular Machinery"//, Dpt of Chemistry, Rikkyo University, Tokyo (Japan). [[http://www-isis.u-strasbg.fr/doc/conf-IRIE.pdf|pdf]] |
| - | * June 20th, 2008, Dr. **Hendrik Dietz**, //"Building molecular machinery using DNA"//, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School | + | * June 20th, 2008 Dr. **Hendrik Dietz**, //"Building molecular machinery using DNA"//, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School |
| - | * June 9th, 2008, Prof. Eric Westhof, //"The modular assembly of RNA architectures"// [[http://www-ibmc.u-strasbg.fr/upr9002/westhof/|IBMC]], Strasbourg | + | * June 9th, 2008 Prof. Eric Westhof, //"The modular assembly of RNA architectures"// [[http://www-ibmc.u-strasbg.fr/upr9002/westhof/|IBMC]], Strasbourg |
| - | * May 28th, 2008, 14h00, Prof. **K.C. Nicolaou**, //"Perspectives in Total Synthesis"//, Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, Chemical Synthesis Laboratory @ Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), Singapore | + | * May 28th, 2008 Prof. **K.C. Nicolaou**, //"Perspectives in Total Synthesis"//, Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, Chemical Synthesis Laboratory @ Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), Singapore |
| * May 5th, 2008, Prof. **Klaus Müllen**, //"Structural Complexity in Molecular Electronics"//, [[http://www.mpip-mainz.mpg.de/groups/muellen/|Max-Planck Institute for Polymer Research]] - Mainz | * May 5th, 2008, Prof. **Klaus Müllen**, //"Structural Complexity in Molecular Electronics"//, [[http://www.mpip-mainz.mpg.de/groups/muellen/|Max-Planck Institute for Polymer Research]] - Mainz | ||
| - | * March 19th, 2008, 16h, Prof. **Steven Rokita**, //"Nucleotide Sequence Controls the Efficiency of Electron Injection and Transport in Duplex DNA"//, College Park, University of Maryland, USA | + | * March 19th, 2008 Prof. **Steven Rokita**, //"Nucleotide Sequence Controls the Efficiency of Electron Injection and Transport in Duplex DNA"//, College Park, University of Maryland, USA |
| - | * March 3rd, 2008, 14h, Prof. **Johan Hofkens**, //"Probing (bio)molecular dynamics by single molecule spectroscopy"//, Université de Leuven, Material Research Center, de Heverlee (Belgique) | + | * March 3rd, 2008 Prof. **Johan Hofkens**, //"Probing (bio)molecular dynamics by single molecule spectroscopy"//, Université de Leuven, Material Research Center, de Heverlee (Belgique) |
| - | * January 22nd, 2008, 16h, Prof. **Franck McKeon**, //"p73 and Airway Inflammation : New Mechanisms of the Innate Immune Response"//, Dept. of Cell. Biology, Harvard Medical School, Boston, USA | + | * January 22nd, 2008 Prof. **Franck McKeon**, //"p73 and Airway Inflammation : New Mechanisms of the Innate Immune Response"//, Dept. of Cell. Biology, Harvard Medical School, Boston, USA |
| - | * January 14th, 2008, Prof. **Stefan Hell**, Max Planck Institute for Biophysical Chemistry, Göttingen [[http://www.mpibpc.gwdg.de/groups/hell/personals/shell.html]] | + | * January 14th, 2008 Prof. **Stefan Hell**, Max Planck Institute for Biophysical Chemistry, Göttingen [[http://www.mpibpc.gwdg.de/groups/hell/personals/shell.html]] |